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The FDA made this determination after receiving numerous complaints from patients, providers, manufacturers, compounders, and other stakeholders that these drugs were unavailable on the market

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10.1016/j.pupt.2010.01.002 45 RheeJ.LeeK.KimD.LeeY.JeonO.KwonH.et al (2007)

In particular, the contribution of HDAC4 to the sumoylation for MEF2 finally leads to transcription inhibition [80] while HDAC4-mediated sumoylation of ZXDC activates the transcription activity [81]