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Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M

Muscles heal in weeks because they have abundant blood supply delivering oxygen, nutrients, and growth factors directly to the injury site

1G) demonstrated a similar increase in mRNA and protein expression of iNOS and SLC25A33 in LPS/IFN--treated macrophages (Fig

By taking advantage of the potent catalytic activity of TYR that is mechanistically validated by ab initio molecular dynamics (AIMD) theoretical calculation and experimental catalysis performance, we develop a TYR-catalyzed in-situ formed proteolysis-targeting chimeras (PROTACs) to degrade intracellular TYR protein to decrease melanin synthesis for treating hyperpigmentation and a TYR-catalyzed in-situ activated prodrug strategy to overcome drug resistance for melanoma therapy

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