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EMBO J 43(23):61996231

HSP90 also promotes tumor angiogenesis by enhancing the transcription and expression of vascular endothelial growth factor receptors (VEGFRs), which are essential for endothelial cell-dependent angiogenesis

Haematol 35 , 331340 (1977)

Polyphyllin -Induced ferroptosis in MDA-MB-231 triple-negative breast cancer cells can Be protected against by KLF4-mediated upregulation of xCT

Furthermore, histopathological observations on both H & E staining and Oil red O staining demonstrated serious hepatic steatosis and cardiac tissue damage with lipid droplets in HM groups contrasted to the control group due to higher lipid profile and increased cellular toxicity marker such as ALT, AST, ALP, LDH and CK-MB level