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anti-estrogens including, for example, tamoxifen, raloxifene, aromatase inhibiting 4(5)-imidazoles, 4-hydroxytamoxifen, trioxifene, keoxifene, immunosuppressive agents include, but are not limited to 2-amino-6-aryl-5-substituted pyrimidines, azathioprine, cyclophosphamide, bromocryptine, danazol, dapsone, glutaraldehyde, anti -idiotypic antibodies for MHC antigens and MHC fragments, cyclosporin A, steroids such as glucocorticosteroids, cytokine or cytokine receptor antagonists (e.g., anti-interferon antibodies, anti-ILlO antibodies, anti-TNFa antibodies, anti-IL2 antibodies), streptokinase, TGFP, rapamycin, T-cell receptor, T-cell receptor fragments, and T cell receptor antibodies

In some embodiments, Lipid Nanoparticles (LNPs) are formulated to encapsulate a pharmaceutical agent (e.g., siRNA) using a spontaneous vesicle formation formulation procedure, as previously described in Semple et al (2010) nat

The efficacy of ADCC and CDC, and consequently response rates observed in GEN501 and SIRIUS trials, are directly proportional to CD38 expression levels on MM cells

Finally, the sections were coverslipped using NEW M.X (Matsunami-glass)