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The dithiol mechanism was too slow to compete with the monothiol mechanism in the presence of GSH or GSSG and was only detected for the oxidation of roGFP2 using diamide-treated PfGrx without GSH

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Psychiatry 13 (11), 950958

Cell 156 , 771785 (2014)

Additionally, their functions are linked to their cellular localization, which demonstrates an evolutionary relationship between the studied isoforms and their role in plant defense