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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

Bioactive peptides Bioactive substances are found in organic matter, such as plants, animals, and animal products, so bioactive peptides might also be categorized as natural peptides.10 Bioactive peptides can be consumed via dietary sources, including but not limited to eggs, soy, legumes, meat (including seafood), and dairy.11 Or else they can be isolated, extracted, and processed into oral or even topical supplements

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Store unopened vials at -20C (freezer) and reconstituted solutions at 2-8C (refrigerator) for optimal stability and shelf life

The route of administration in all published studies has been intraperitoneal injection in mice