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Complete cessation typically results in gradual return to baseline over 4-8 weeks

Adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) is a key regulatory protein of mitochondrial mass (117), and its activation significantly inhibits the activation and proliferation of RA-FLSs (118)

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Cardiovascular effects Oxidative stress-induced intracellular redox imbalance plays a pivotal role in the pathogenesis of various cardiometabolic risk factors (hyperlipidaemia, hypertriglyceridemia, hyperglycemia, hypertension, obesity) leading to severe cardiovascular diseases