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Besides genetic alterations, epigenetic mechanisms have recently emerged as key regulators of gene expression inducing transcription activation or silencing of cancer-related genes and, consequently, the alteration of signaling pathways involved in the regulation of the cell cycle, differentiation, metabolism, cell growth and proliferation, and DNA repair mechanisms [7,8,9,10,11]

Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies

Front Drug Deliv

Friesner, R

Meanwhile, complement factor C3 deficiency attenuates arterial thrombosis in mice due to the disruption of the C3a-C3a receptor axis in platelets (113)