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Global economic productivity losses from vision impairment and blindness

Zheng, Y., Nguyen, J., Wei, Y

In vivo , the sperm-zona pellucida binding triggers a cascade of signal transduction reactions that culminates in an significant increase in intracellular Ca 2+ levels required for acrosomal exocytosis (83)

Our findings demonstrate that this mucoadhesive, nano-enabled system successfully overcomes the primary bottleneck of conventional therapies (the blood-brain barrier) leading to significantly enhanced neuro-restoration, reduced oxidative stress, and suppressed neuroinflammation in a PD model