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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

"Nuclear transport, oxidative stress, and neurodegeneration"

The food-derived glutathione levels within the protein-bound fraction between the plasma from the portal vein and from the inferior vena cava were insignificantly different, which indicates that glutathione in the low-molecular-weight fraction may be preferentially incorporated into the liver

JCI Insight (2021) 6(20):e151911