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Despite this ancestral function, they are highly dynamic organelles that act as metabolic hubs, regulating calcium homeostasis, heme synthesis, and the genesis of crucial intermediary metabolites in the tricarboxylic acid (TCA) cycle, some of which act as the building blocks for the synthesis of lipids required for membrane assembly [108111]

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42,43 Cholesterol-enriched lipid droplet formation in podocytes, combined with dysregulated insulin signaling and hyperglycemia, exacerbates podocyte death and detachment

& Berti, G