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Animal models that lack genes responsible for protecting the guts epithelium, such as Mdr1a/, Irgm1/, and Sod2/ transgenic mice, exhibit an increased presence of impaired mitochondria in intestinal cells and are more susceptible to experimentally induced colitis (56)

[32] Factors affecting formulations Various physical and chemical factors are involved in the formulation of topical emulsion or cream preparations, [37],[38],[39],[40],[41] some of which are briefly described below: Choice of emulsion type Oil-in-water emulsions are used for the topical application of water-soluble drugs, mainly for local effect

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Oxidative toxicology of bleomycin: role of the extracellular redox environment