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Additionally, in a monkey model of PD, GDNF infusion in the lateral ventricles or the striatum significantly improved motor function, which was associated with upregulation and regeneration of nigral dopaminergic neurons and their innervation to the striatum [45]

Moreover, while many of the reviewed studies reported promising feasibility and adherence to VR-based interventions, these results were mostly obtained in highly structured clinical or research environments

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Most MS studies utilize structural MRI for identifying lesions and determining if they are active based on gadolinium enhancement ( Materials and Methods Overview of Study Written informed consent, approved by the Institutional Review Board of Thomas Jefferson University, was obtained from all subjects and the study was registered on clinicaltrials.gov with the following identifier: NCT03032601

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