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study, GHK-Cu increased fibroblast production of decorin by 302% at 1 nanomolar [34].[4] Strong systemic wound healing was induced in pigs at about 1.1 mg GHK-Cu per kilogram body weight which would correspond to about 75 mgs in humans

In an outer-sphere mechanism, the metal is oxidized or reduced by a group not directly coordinated to the metal cofactor

More specifically, the researchers posited that IGF-1 LR3 cleared faster as it appeared to bind to a lower degree to binding proteins than endogenous IGF-1

For example, in a 3-week prospective intervention with a high dose of 100 mg riboflavin/day with 70 patients with Crohns Disease, a reduction in systemic oxidative stress (measured by higher free thiol plasma levels), inflammatory markers (IL-2 and C-reactive protein (CRP)) and clinical symptoms of Crohns disease (i.e., a reduction in clinical disease activity index and quality of life improvement) were observed 52

PMID 12379275