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Affected individuals who present with symptoms despite a lack of environmental Mn exposure consistently exhibit severe hypermanganesemia, dystoniaparkinsonism, chronic liver disease, and polycythemia

Applications of Ultrasound-Driven BTNPs in Treating Tumors Across Various Tissues Breast Cancer Researchers have focused on applying the piezoelectric effect of BTNPs under US stimulation for breast cancer treatment, developing various BTNPs for this purpose ( Citation80 Studies have shown that alleviating hypoxia can reduce HIF-1 levels, thereby inhibiting tumor metastasis

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Moreover, elevated CUL3 levels are linked to a negative outlook in cases of breast and ovarian cancers, indicating its involvement in facilitating the growth of tumor cells in these scenarios (254)

As illustrated in Figure 1, Hcy is a central intermediate in both the Met cycle and the transsulfuration pathway, and its levels are tightly regulated to maintain metabolic homeostasis