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Conclusion: Aggregate safety outcomes across 4 global clinical studies suggest that the safety profile of the combination of tobevibart and elebsiran observed to date is generally consistent with the reported class effects of RNAi therapeutics and monoclonal antibodies

It supports enzyme activity, immune signaling, DNA synthesis, and cellular repair

doi: 10.7759/cureus.50782 160 Committee on Strategies for Responsible Sharing of Clinical TrialDataBoard on Health Sciences PolicyInstitute of Medicine

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Another important unanswered question concerns the pathophysiological interactions between astrocytes and other glial cells, such as microglia and oligodendrocytes, under neurodegenerative conditions and their associated microenvironments