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The trial evaluated once weekly cagrilintide doses in participants with overweight or obesity and reported dose dependent reductions in body weight at 26 weeks, with the paper describing the treatment as well tolerated in the study setting

Nearly one-third of tirzepatide participants achieved at least 25% total body weight loss, compared to 16% on semaglutide

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Many do not, because the compound quality is unverified, the dose is based on internet research rather than clinical assessment, and there is no baseline, no follow-up, and no protocol adjustment based on individual response