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Biotin (1 mM in PBS, sterile filtered) was added to a final concentration of 50 M at the indicated timepoint, and cells were fixed and stained 24 h after seeding

229,230 Interestingly, in a patient with SCO2 mutations who presented with severe hypertrophic cardiomyopathy, Cu-histidine supplementation has been reported to improve heart function, showing attenuated cardiomyopathy as well as the normalization of blood pressure

doi: 10.1016/S0959-4388(02)00290-8 65 HuangY.LiJ.LiW.AiN.JinH

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