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Enzymes work like small machines continuously processing while suitable substrate and conditions are available

AAB59203, a.a

PubMed Berg MJ, Stumbo PJ, Chenard CA, et al

The aim of the current study was to estimate the Cu(II)-binding affinities of major serum copper proteins (HSA, CP and 2M) in comparison with LMW Cu(II)-binding reference ligands including His by using an unified and direct approach, which gives thermodynamic background for understanding the distribution copper in the blood

The United States had the highest number of DHT-enabled trials (92, 39.3%), followed by the United Kingdom (15.0%), France (8.1%), and Australia (5.1%), while China accounted for only three trials (1.3%) (Supplementary Fig