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It could be shown that antioxidants such as D--tocopherol and probucol can restore the strong glucose-induced decrease in DGK activity and that H 2 O 2 mediates a downregulation of DGK activity, strongly suggesting a redox-dependent regulation of DGK 74

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ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling

Halogen facilitates the binding with the enzyme because it increases the binding affinity and binding selectivity, and adding halogens to lead during drug development is well recognized to be a general optimizing approach [31]

Persidsky, Y., Ramirez, S