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10.3390/antiox10101503 40 LnonM.KeN.SzadyC.SakhtahH.RenG.MantaB.et al (2020)

7, July 2021, p

Activated PI3Ks phosphorylate the lipid phosphatidylinositol (4,5)-bisphosphate (PIP2) to generate phosphatidylinositol (3,4,5)-trisphosphate (PIP3) (51)

Maintaining optimal levels of glutathione is essential for supporting your body's natural defence mechanisms and promoting overall vitality

Note also that GSH inhibits both GCL and GS, so it is not clear by inspection of the diagram what the effect of raising the activities of GCL and GPX will be