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NRF2 activity is also regulated by the availability of many binding partners, including a group of bZIP bi-directional transcription regulators named sMaf proteins (MafF, G and K) [200, 201] which, when bound to NRF2, under OS, favor its maintenance inside the nucleus thereby enhancing its activity [202]

doi: 10.1093/toxsci/kfz077

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This location suggests that nodules are the result of phonotrauma, the physical stresses on the vocal fold occurring with heavy voice use or voice use under adverse circumstances