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Cytokinergic IgE activity may provide a rationale for the paradoxical observation that the risk of developing an allergic disease and severity of the disease is more closely related to the levels of total IgE than allergen-specific IgE in serum (Burrows et al., Germinal Center Reactions and the Local B Cell Repertoire)

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The compound 97 was shown to inhibit expression of iNOS and COX-2 in RAW264.7 cells, it suppressed also the production of interleukin 6 and TNF- (Baek et al