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The major problem is that no effective method exists to find the cause

Hirrlinger J, Konig J, Keppler D, Lindenau J, Schulz JB, Dringen R

It is noteworthy that the mechanisms of acute and chronic OIPN are not identical

In the TME, DCs play a key role in capturing, processing, and presenting tumor-associated antigens, as well as providing co-stimulation and soluble factors to regulate T-cell responses (70)