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Endogenous defense activators The NRF2/KEAP1 pathway boosts the cells inducible antioxidant defenses, which is especially useful under chronic, low-grade oxidative stress

While studies conducted in puppies and aged dogs suggest an improvement of immune status with dietary supplementation of different functional additives (organic selenium, curcumin, gallic and gallnut tannic acids and -carotene), there is a significant lack of evidence regarding the potential influence of these compounds in the immune system of these dogs