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The first relates to weight reduction, which is important as obesity is one of the factors contributing to psoriasis exacerbation (201, 205)

Lightening vs

PPT1 inhibition induced lysosomal lipid peroxidation (LLP), which led to lysosomal membrane permeabilization and cell death that could be reversed by the antioxidant N-acetylcysteine (NAC) but not by other lipid peroxidation antioxidants

Taking more does not always mean better results, so we must follow recommended amounts

Phase 2 trials have included striatal binding of dopamine transporter in the secondary outcome measures (NCT03100149, NCT03318523, Table 2), which would be of interest to correlate with the clinical outcome measures, and the biofluid-measured alterations to improve understanding of the drug action mechanism