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Development and in vivo evaluation of Irinotecan-loaded Drug Eluting Seeds (iDES) for the localised treatment of recurrent glioblastoma multiforme

Reactive protein isoforms differ in their effects on thrombus growth

Wash with PBS one more time and add 500 l of lysis buffer (0.1% Triton-X and 0.6% sulfosalicylic acid in 0.1 M potassium phosphate buffer with 5 mM EDTA at pH 7.5) on ice

We determined the duration of the washout period based on the estimated complete turnover time of GSH synthesis in the brain ( Randomization The study randomization and intervention timeline are illustrated in Figure 2

Further doseresponse and steady-state administration studies will be required to optimize the dosing schedule for future trials to evaluate therapeutic efficacy