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The increased LPS in the blood has been demonstrated to cause the liver injury in DSS-induced mice (Guan et al., 2022)

Portions of this research used high-performance computing resources supported by the University of Arizona Technology and Research Initiative Fund (TRIF), University Information Technology Services (UITS), and Research, Innovation, and Impact (RII), and maintained by the University of Arizonas Research Technologies department

Kodama et al., 2020

The cells were then incubated for 3 h at 37 C and 5% CO 2 , followed by two washes with 1 PBS to remove non-internalized siRNA or liposomes

GHK-Cu addresses this cascade at multiple points simultaneously