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Indeed, we performed RNA-seq of 5 hyperplastic and 3 normal prostate specimens and found that there was a number of DEGs between hyperplastic prostate and normal prostate, of which the up-expressed matrix-remodeling associated 5 (MXRA5) [9], C-X-C motif chemokine ligand 13 (CXCL13) [10], bone morphogenetic protein 5 (BMP5) [11] and neural epidermal growth factor-like like 2 (NELL2) [12], and the down-expressed glutathione peroxidase 3 (GPX3) ranked at the top and most of them have been reported

These studies should investigate diverse populations and examine potential interactions with other factors influencing metabolism

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