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Acromegaly Kidney morphology Acromegaly is associated with renal hypertrophy in humans and rodents [1]

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This hypothesis was recently challenged by a number of important discoveries, including a seminal study examining skeletal development in mice with liver-specific deletion of the Igf-I gene ( Liver IGF-I / ) (3,4)

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To exert these apparent effects, CJC-1295 appears to interact with specific binding sites on the GHRH receptor protein, leading to conformational changes in the receptor structure and potentially initiating a cascade of molecular events