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Therefore, once the ATP7B gene is expressed abnormally, it leads to impaired synthesis of ceruloplasmin (the major copper-containing protein in the blood) in the liver as well as impaired biliary excretion process of copper in the liver, which ultimately leads to overaccumulation of copper in the liver

Med (Baltim) 102(46):e35951

11 , e01074 (2023)

Deuterium-reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntingtons disease