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Importantly, VGF suppression using sh-VGF adenovirus abolished the glutamine- and alanine-induced glucagon hypersecretion (Fig

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Furthermore, increased expression of heme oxygenase-1 (HO-1) in microglia and loss of copper chaperone protein (CP) activity in astrocytes contribute to iron deposition in the central nervous system (CNS) and neuronal death [182]