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Several mechanisms have recently been proposed to explain the augmented OS during obesity, including altered glucose and lipid homeostasis, systemic inflammation, hyperleptinemia, and abnormal postprandial ROS production (122)

MALAT1-knockout mice are hypersensitive to DSS-induced experimental colitis, and the absence of MALAT1 induces dysregulation of the intestinal mucosal barrier and disrupts intestinal homeostasis (Li et al., 2021)

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Results revealed that out of 10 docked receptors, amyloid beta showed the highest binding affinity with an energy of 46.1 kcal/mol showing promising drug for Alzheimer's disease