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In aging and neurodegenerative disease (AD and to a greater extent, PD), the basal forebrain cholinergic neurons (nucleus basalis of Meynert), the origin of cholinergic enervation of the cortex and hippocampus, are susceptible to cell loss and tau deposition [214,215,216,217]

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Similarly, patients with MDD also had decreased relative abundance of the genera Coprococcus and Faecalibacterium compared to non-depressed individuals in a meta-analysis by Sanada et al

Supplementary Data 1) as well as Fzd1 , Map2 , Robo2 , Zic1 and Dll1 (Supplementary Fig