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Significant behavioral abnormalities, decreased antioxidant defense, and an increase in inflammatory markers such as GFAP, iNOS, intercellular adhesion molecule (ICAM), and tumor necrosis factor-gamma (TNF- ) were observed in pars compacta of substantia nigra (SNpc) of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced PD mouse model

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As the COSM ro model did not account for cholesterol transport across cell membranes, we investigated experimentally the potential contribution of cholesterol uptake and efflux to the decreased cholesterol in rSCC-61 cells

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The effect can vary between virus strains, viruses grown in different cell types and different target cells