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Microorganisms, including Escherichia coli or Clostridium species, produce enzymes like beta-glucuronidase, which hydrolyse conjugated bilirubin back into its unconjugated form, increasing the probability of precipitation [27, 35]

Neurological symptoms like numbness and tingling may take longer to improve sometimes several months and in severe cases, some nerve damage might be permanent

18th World Congress of the World Society of Cardio-Thoracic Surgeons, 2008

A recent epidemiological study revealed that the worldwide prevalence of FC and IBS-C in adults is 11.7% and 1.3% respectively [2]

Some studies have found that intermittent hypoxia leads to the following changes: a decrease in total antioxidant capacity, an increase in MDA serum levels, a decrease in the activity of antioxidants (SOD, GSH-Px and GSR) of the testis and epididymis and a significantly reduced number of epididymal sperm [23, 24]