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NEWS Update 20 January 2025 2024 FDA approvals Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature Reviews Drug Discovery 24 , 75-82 (2025) doi: Updates & Corrections Update 20 January 2025 : Information on the financial performance of the new drugs approved and the characteristics of the reviews by the FDA has been added to the article, with an additional column in Table 1 and addition of Figure 4.

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Moreover, QUE triggered lysosomal activation by promoting the nuclear translocation of EB and activating the transcription of lysosomal genes