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PLoS ONE 16:e0259317

Pinched spinal nerve: This, also known as radiculopathy, may cause the muscle to twitch alongside other symptoms, including feeling numb or tingling in the leg or foot

It was recently shown that pemetrexed may play a role in cisplatin resistance in lung cancer by increasing the expression of Orai3 calcium channels as well as the expression of certain ABC transporters like MDR1 and MRP-5 responsible for cisplatin efflux and therefore a reduction of the effect of cisplatin [16] As current therapies are based on the co-administration of pemetrexed and cisplatin, there may be interactions between pemetrexed and cisplatin, including a reduction in the therapeutic effects of cisplatin caused by pemetrexed

Characterization of the human Omega class glutathione transferase genes and associated polymorphisms