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Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating taus ability to bind and stabilize microtubules

The entire secondary structure is rather irregular and very rigid because of disulfide clips

[DOI] [PubMed] [Google Scholar] 197.Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, et al

Overexpression of miR-506 in cholangiocytes leads to multiple PBC-like features, including impaired cell proliferation and adhesion, sensitization to bile acid-induced apoptosis, impaired energy metabolism, PDC-E2 overexpression and mislocation into the plasma membrane, and immune activation

Together, they create a synergistic effect where the whole exceeds the sum of its parts