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Proteomic analyses confirmed enrichment of ER and autophagy pathways, and pharmacological inhibition of ER stress alleviated autophagic dysfunction and cellular injury, supporting a causal role for ER perturbation in cardiomyocyte toxicity [28, 161]

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Malnourishment, eating disorders, and cachexia (muscle wasting) can also increase the risk of liver injury following overdose (Ferner 2011)

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