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In this regard, there is no doubt that the BBB exists primarily through the coordination between cells, and astrocytes are a type of neural cells that together with pericytes surround blood vessels in the brain, serving as the interface between neurons and endothelial cells

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NPTAs are nanoscale entities with a substantial surface area that can generate ROS under biological conditions, inducing cellular apoptosis by modifying protein structures, peroxidizing lipids, and inflicting DNA damage