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Individual reactions and safety profiles can vary significantly

This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (40, 42)

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42 Stabilizing cardiolipin or enhancing its translocation improves mitochondrial clearance and reduces oxidative stress in heart failure models, 43 while enzymes involved in cardiolipin metabolism, such as tafazzin, represent additional therapeutic opportunities

and 2) hydroxylation (probably at the 4'-and 5-arene positions) followed by conjugation to taurine, glucuronic acid or glucose