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4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress

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NAC, a precursor to glutathione, is a powerful cellular antioxidant used as free radical scavenger antioxidant in its own right

The process of lipid droplet degradation through autophagy is called lipophagy ( Figure 1 ) can promote RSL3-induced lipid peroxidation and ferroptosis in human liver cancer cells ( Degradation of circadian regulator The circadian clock is endogenous and controls numerous cellular physiological processes, including iron metabolism, oxidative stress, and cell death, by regulating circadian switches ( Figure 1 ), supporting that SQSTM1 is a multisubstrate autophagy receptor for ferroptosis