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The specific mechanism of editing is idiosyncratic to each synthetase but in general, once formed the aa-tRNA triggers a conformational change and the 3 terminus containing the aa is translocated from the active site to the editing site, sometimes traversing distances as large as 40 (Silvian et al

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The Roles of Vitamin C in Skin Health

10.1016/j.cell.2020.08.007 70 MatsuokaK.KanaiT

If a doctor has flagged elevated oxidative stress markers on a blood panel, low glutathione status is one plausible contributor, alongside smoking, alcohol, poor sleep and chronic inflammation