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Cuglievan, B, Kantarjian, HM, Rubnitz, JE, Cooper, T, Zwaan, CM, Pollard, J, DiNardo, C, Kadia, TM, Guest, E, Short, NJ, McCall, DC, Daver, N, Nunez, CA, Haddad, FG, Garcia, MB, Bhalla, K, Maiti, A, Catueno, S, Fiskus, WC, Carter, BZ, Gibson, A, Roth, M, Khazal, SJ, Tewari, P, Abbas, HA, Bourgeois, W, Andreeff, M, Shukla, N, Truong, D, Connors, JS, Ludwig, JA, Stutterheim, J, Salzer, E, Juul-Dam, KL, Sasaki, K, Mahadeo, KM, Tasian, SK, Borthakur, G , Dickson, S, Jain, N, Jabbour, EJ, Meshinchi, S, Garcia-Manero, G, Ravandi, F, Stein, EM, Kolb, EA, Issa, GC

[54], evaluated cellular toxicity and mitochondrial dysfunction during cellular senescence in rat brain tissue exposed to -radiation, and assessed the therapeutic potential of curcumin nanoparticles

Also, increased ROS production can be attributed to the activity of the pro-oxidant enzymes NADPH oxidases (NOXs) [113]

10.3389/fnut.2021.635232 65 LuczakE

HSPA1A upregulates the MAPK phosphatase Dual-Specificity Phosphatase 1 (DUSP1), which dephosphorylates p38, c-Jun N-terminal kinase (JNK) and Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2)