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Animal experiments C57BL/6 J mice purchased from three Gorges University Animal Center (Yichang, Hubei, China) was used in this study

Common side effects (may affect up to 1 in 10 people): * Pain, redness, or swelling at the injection site * Nausea * Headache Uncommon side effects (may affect up to 1 in 100 people): * Diarrhea * Dizziness * Allergic reactions such as skin rash, itching, or hives Rare side effects (may affect up to 1 in 1,000 people): * Severe allergic reaction (anaphylaxis) with symptoms like difficulty breathing, swelling of the face or throat, and a drop in blood pressure

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