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MiR-21 is widely expressed in human tissues and is upregulated mainly in non-parenchymal liver cells such as HSCs, inflammatory cells, and biliary cells [290, 304]

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Notably, Nrf2 plays a dual protective role by both repressing neuroinflammatory signaling and promoting the transcription of antioxidant genes, establishing it as a compelling therapeutic target in neurodegenerative disorders [182, 183]

reported that EGFR regulates the expression of the TFR through the tyrosine kinase pathway, thereby affecting the iron uptake capacity of lung cancer cells [48]