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8 10 Similarly, oxidative stress, via hydrogen peroxide production, is sufficient to convert normal fibroblasts to activated myofibroblasts

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Among them, System X c is the key upstream node, GSH is the main cofactor, and GPX4 is the central regulator (Li et al., 2022)

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A double-blinded RCT evaluated the use of glutathione for the prevention of paclitaxel/carboplatin-induced peripheral neuropathy