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Yanez-Mo M, Siljander PR, Andreu Z, Zavec AB, Borras FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, et al

Common impurities to check include truncated peptide sequences (Gly-His or His-Lys fragments), residual coupling reagents and protecting groups, counterion residues, free (uncomplexed) GHK, and excess copper salts

Implicated specifically were increased angiogenesis, elevated vascular endothelial growth factor (VEGF) levels, upregulation of the early growth response (egr-1) gene, enhanced nitric oxide (NO) and NO-synthase (eNOS) stimulation, and counteraction of increased free radical formation [1]

doi: 10.1002/art.39819 101

4B), suggesting that enhancement in the dopaminergic neurotransmission can exert therapeutic effects on symptoms of ADHD