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In heart tissue from myocardial infarction mice, the expression of the M1 marker nitric oxide synthase 2 (NOS2) was substantially upregulated compared with that of the control group, while the expression of the M2 marker interleukin-10 was significantly downregulated [82]

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However, research conducted with rams has shown promising results regarding the use of RPM supplementation, which may serve as a valuable reference for future studies in other species, including cattle

The honest position supported by both major 2026 reviews is that the preclinical evidence is mechanistically compelling, no major safety red flags have emerged, and controlled human evidence has been entirely absent

doi: 10.1016/S0140-6736(23)00457-9 115 PooleBDTempletonAKGuthridgeJMBrownEJHarleyJBJamesJA